Abstract: In order to solve the problems of low treatment efficiency, high treatment cost of waste drilling fluids in the Linxing-Shenfu Well Area, a technical research on harmless treatment and reuse technology of waste drilling fluids was carried out. After analyzing the characteristics of the waste drilling fluids and the difficulties in the treatment, a non-toxic composite curing agent with low cost and high efficiency, as well as aluminum salt gel breaker were developed, and the gel-breaking filtrate produced was processed for compound drilling fluids. Combined with the reduction treatment equipment, a harmless treatment and reuse technology of waste drilling fluids was formed. The field test results showed that the liquid content of cuttings was less than 30% and the weight of cuttings reduced by 20%–40% after the separation of the waste drilling fluids by reduction treatment equipment. The waste drilling fluids with high solid content can be directly transported 24 hours after the addition of 15% curing agent, and the leaching fluid can meet the requirements for environmental protection after 3 days. When a 4.29% gel breaker was added to the waste drilling fluids with high water content, a high-efficiency gel breaking can be achieved. The gel-breaking filtrate can be used for compound drilling fluids after treatment, which can meet the operational requirements for drilling. The harmless treatment and reuse technology of waste drilling fluids have solved the problem in treating waste drilling fluids in Linxing-Shenfu Well Area, with good promotion and application value.