Abstract: With the rapid development of artificial intelligence (AI) technology, it has made remarkable breakthroughs in many fields. However, the application of AI in drilling engineering is still in the primary stage. In order to promote the application of AI technology in drilling, based on a brief description of the research situation of its application in drilling engineering, a “three-wheels drive” methodology for the specific application of AI technology in drilling area was proposed. Then, business application scenarios and AI technology tools suitable for the research of AI in drilling engineering were analyzed. After putting forward a method of evaluating and optimizing projects based on the methodology with examples, the research process of AI application in drilling was illustrated by the real-time diagnosis of complex downhole failures. Finally, the shortcomings were identified and suggestions were given for the application of AI in drilling engineering, so as to promote the development of AI drilling technology.